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KMID : 1059520120560040473
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Journal of the Korean Chemical Society
2012 Volume.56 No. 4 p.473 ~ p.477
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Preparation and Drug-releasing Properties of Chitosan-based Thermosensitive Composite Hydrogel
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Li Heping
Yu Tao
Li Shan
Qin Long
Ning Jingheng
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Abstract
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The novel chitosan-based thermosensitive hydrogels were prepared as control-releasing drug carriers. N-carboxyethyl chitosan (ACS) was synthesized by microwave heating for 1 h through Michael addition of CS to acrylic acid in a grafting yield of 52.97%, which was proved to be a faster and more efficient way than ordinary methods. 5-Fu was modified with formaldehyde to synthesize N,N’-Bis(hydroxymethyl)-5-fluorouracil (5-Fu-OH). Then an esterification was performed using ACS and 5-Fu-OH to give 5-Fu-ACS. The new thermosensitive hydrogels were prepared by adding sodium glycerophosphate to the solution of compounds under a certain constant temperature. Simultaneously, the hydrogels’ swelling rate, in vitro drug release rate and thermosensitive were studied, and found that the 5-Fu-ACS composite hydrogel had more excellent releasing effect, higher drug loading and better thermosensitive.
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KEYWORD
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Chitosan, Acrylic acid, Microwave heating, Thermosensitive hydrogel, Drug releasing
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